منابع مشابه
Dicing up chromosomes: the unexpected role of Dicer in apoptosis.
4772 Cell Cycle Volume 9 Issue 24 Apoptosis is an evolutionarily conserved and tightly reglated process in which caspases, a unique family of cysteine proteases, direct the dismantling of a dying cell. A fundamental feature of apoptosis is chromosome fragmentation, which is executed by multiple apoptotic nucleases in a stepwise manner. Apoptotic nucleases first introduce 3’ hydroxyl nicks into ...
متن کاملCentromeres
Also known as... The terms ‘centromere’ and ‘kinetochore’ are often used synonymously but it is best to consider the centromere as the DNA and chromatin on which the kinetochore is assembled and the kinetochore as the protein machine, including centromeric chromatin, which mediates attachment to the spindle. Centromeres are found near the centre of the chromosome on metacentric chromosomes, but...
متن کاملUp-Regulated Dicer Expression in Patients with Cutaneous Melanoma
BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs (18-24 nucleotides) that have recently been shown to regulate gene expression during cancer progression. Dicer, a central enzyme in the multi-component miRNA biogenesis pathway, is involved in cutting precursor miRNAs to functionally mature forms. Emerging evidence shows that Dicer expression is deregulated in some human malignancies and i...
متن کاملCentromeres
Centromeres, chromosomal regions that become physically linked to the spindle during cell division, ensure equal division of genetic material between daughter cells. They are ubiquitous and essential in eukaryotic life. In this primer, we ask the questions 'What defines a functional centromere?' and 'What do all centromeres have in common?' To address these questions we highlight what is known ...
متن کاملTransmission Experiments with Leucosis of Fowls
It is shown, in a carefully controlled experiment, that fowl leucemia can be readily transmitted from chicken to chicken by injection. Of 25 fowls, 13 were injected intravenously with blood from a chicken (No. 575) with erythroleucosis and 12 with blood from a chicken (No. 689) with myeloid leucosis. The injected birds and an equal number of uninjected controls were kept in tiers of alternating...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2004
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0804-696